Researchers have found a new way to stop the growth of glioblastoma, which is the most dangerous type of brain tumour. A study led by The Ohio State University Comprehensive Cancer Center has discovered that an enzyme called PGM3 plays a key role in helping these tumours grow.
By targeting this enzyme, scientists believe they can slow down or even stop the growth of glioblastoma.
PGM3 is important in a process called the hexosamine synthesis pathway. This pathway helps in protein and lipid glycosylation, which is when sugar molecules attach to proteins and fats in the body.
These processes help tumours grow faster. By blocking PGM3, researchers say they can stop this sugar and fat connection, which may prevent the tumour from growing.
Deliang Guo, the lead author of the study and founding director of the Center for Cancer Metabolism, said this discovery is very important. The study was published in the journal Science Advances.
Glioblastoma is a very fast-growing brain tumour that starts from glial cells in the brain. About 15,000 people are diagnosed with this deadly cancer every year, according to the Glioblastoma Foundation.
Most people with glioblastoma live only 12 to 16 months after diagnosis, even with strong treatments. So, doctors and scientists say it is very important to find new ways to treat it.
The research team also included scientists from France, the University of California-Los Angeles, University of California-Irvine, and University of Louisville.
